RRs (95% CI) out of overall, ischemic, and you will hemorrhagic shots because of the quintiles of combined diet plan scores to own magnesium, potassium, and you may calcium intakes in 86,149 ladies in the brand new NHS I and you may 94,715 feamales in the newest NHS II step 1
I current the fresh new meta-analyses from prospective education out-of losing weight magnesium ( 21), potassium ( 22), and you may calcium ( 23) intakes and chance of stroke
The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses’ Health Study.
RRs (95% CI) of full, ischemic, and you may hemorrhagic shots because of the quintiles off joint diet score having magnesium, potassium, and calcium supplements intakes from inside the 86,149 ladies in new NHS I and 94,715 women in brand new NHS II 1
We upgraded the latest meta-analyses of potential degree out-of losing weight magnesium ( 21), potassium ( 22), and you will calcium ( 23) intakes and you will danger of coronary arrest
The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses’ Health Study.
We examined separately the relation between intakes of magnesium, potassium, and calcium from supplements and risk of stroke. There was no significant association between supplemental magnesium or calcium intake and risk of total, ischemic, or hemorrhagic stroke in the pooled analyses. We observed a significant inverse association between supplemental potassium intake and risk of ischemic but not total or hemorrhagic stroke. The pooled multivariate RR for comparison of highest with lowest quintiles of supplemental potassium intake was 0.71 (95% CI: 0.56, 0.89, P-trend < 0.01) for ischemic stroke. Pooled multivariate RRs for supplemental magnesium (Supplemental Table 7), supplemental potassium (Supplemental Table 8), and supplemental calcium (Supplemental Table 9) and risk of total, ischemic, and hemorrhagic strokes are shown in the supplemental material.
We examined total and you will fat reduction intakes of each and every mineral and you may chance away from heart attack to decide any potential nonlinear relationship by using restricted cubic http://datingranking.net/over-50-dating splines; yet not, zero tall deviation regarding linearity is noticed. At the same time, i searched the possibility perception modification from the years, blood circulation pressure, otherwise all forms of diabetes to your relation between full consumption of all of the step three nutrients and you can risk of overall coronary attack. Zero tall effect modification are seen by such affairs.
Prior meta-analyses integrated is a result of past analyses on the NHS ( 10); these types of performance were changed because of the leads to the modern research. While doing so, new literature was looked, and you can recent prospective studies ( 8, 24) were included in these updated meta-analyses. No between-studies heterogeneity was seen the of your own step 3 nutritional elements. The fresh new joint RR out of complete coronary arrest try 0.87 (95% CI: 0.83, 0.92) getting an one hundred-mg/d improve out of magnesium intake, 0.91 (95% CI: 0.88, 0.94) having a great 1000-mg/d improve regarding potassium consumption, and you will 0.98 (95% CI: 0.94, step 1.02) to have a 300-mg/d improve of calcium consumption.